Article
Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.
American journal of human genetics - 1 Jun 2008
Valdes Ana M, Loughlin John, Timms Kirsten M, van Meurs Joyce J B, Southam Lorraine, Wilson Scott G, Doherty Sally, Lories Rik J, Luyten Frank P, Gutin Alexander, Abkevich Victor, Ge Dongliang, Hofman Albert, Uitterlinden André G, Hart Deborah J, Zhang Feng, Zhai Guangju, Egli Rainer J, Doherty Michael, Lanchbury Jerry, Spector Tim D
Abstract excerpt
Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illumina550 Duo array was performed in 255 controls and 387 cases. Twenty-eight variants with p < 1 x 10(-5) were...
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