Article
Epistasis and its possible effects on transmission disequilibrium tests.
Annals of human genetics - 1 Nov 2001
Wilson S R
Abstract excerpt
Most approaches to analysing complex genetic disorders are based on an underlying model that assumes that the probability of being affected is mainly due to the effect of a major, single disease locus. Where the penetrance (the conditional probability of being affected) is hypothesised to be influenced by known covariates, methods have been developed to accommodate these covariates appropriately in the analysis....
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