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Article

Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2006

Mitsiades Constantine S, Poulaki Vassiliki, Fanourakis Galinos, Sozopoulos Elias, McMillin Douglas, Wen Zhaoqin, Voutsinas Gerassimos, Tseleni-Balafouta Sophia, Mitsiades Nicholas

Abstract excerpt

PURPOSE: The death receptor Fas is present in thyroid carcinomas, yet fails to trigger apoptosis. Interestingly, Fas has been reported to be actually overexpressed in papillary thyroid carcinomas, suggesting that it may confer a survival advantage. EXPERIMENTAL DESIGN: We investigated the expression and activation status of Fas pathway mediators in thyroid carcinoma cell lines and tumor specimens. RESULTS: All...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16778096
DOI: 10.1158/1078-0432.CCR-05-2493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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