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Article

CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function.

Human molecular genetics - 15 Sept 2018

Quinn Peter M, Alves C Henrique, Klooster Jan, Wijnholds Jan

Abstract excerpt

The mammalian apical-basal determinant Crumbs homolog-1 (CRB1) plays a crucial role in retinal structure and function by the maintenance of adherens junctions between photoreceptors and Müller glial cells. Patients with mutations in the CRB1 gene develop retinal dystrophies, including early-onset retinitis pigmentosa and Leber congenital amaurosis. Previously, we showed that Crb1 knockout mice developed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29893966
DOI: 10.1093/hmg/ddy194

Genes

CRB1
CRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function.PMID 29893966Read ↗

Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotypeSemantic proximity Read ↗

CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in miceSemantic proximity Read ↗

CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retinaSemantic proximity Read ↗

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.Semantic proximity Read ↗

Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital AmaurosisSemantic proximity Read ↗

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.Semantic proximity Read ↗

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.Semantic proximity Read ↗

Towards understanding CRUMBS function in retinal dystrophies.Semantic proximity Read ↗

Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal laminationSemantic proximity Read ↗

Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosisSemantic proximity Read ↗

Crb1 is a determinant of retinal apical Müller glia cell features.Semantic proximity Read ↗

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.Semantic proximity Read ↗

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