Article
Tumor necrosis factor-alpha gene polymorphisms in relation to periodontitis.
Journal of clinical periodontology - 1 Jan 2002
Craandijk Jeroen, van Krugten Michiel V, Verweij Cor L, van der Velden Ubele, Loos Bruno G
Abstract excerpt
BACKGROUND: Genetic polymorphisms for cytokines have been proposed as potential genetic markers for destructive periodontal disease. The present aim was to investigate 4 bi-allelic polymorphisms in the TNF-alpha gene in relation to susceptibility for and severity of periodontitis. The polymorphisms were all transitions from G to A, 3 in the promoter positions: -376, -308, -238; and one in the first intron at...
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