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Article

Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase

12 Jun 2007

Abstract excerpt

The streptogramin combination therapy of quinupristin-dalfopristin (Synercid) is used to treat infections caused by bacterial pathogens, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. However, the effectiveness of this therapy is being compromised because of an increased incidence of streptogramin resistance. One of the clinically observed mechanisms of...

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PMID: 17563376
DOI: 10.1073/pnas.0701809104

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