Characterization of a New Enterococcal Gene, satG , Encoding a Putative Acetyltransferase Conferring Resistance to Streptogramin A Compounds

doi:10.1128/aac.43.7.1813

Article

Characterization of a New Enterococcal Gene, satG , Encoding a Putative Acetyltransferase Conferring Resistance to Streptogramin A Compounds

1 Jul 1999

Abstract excerpt

Streptogramin antibiotics are mixtures of two chemically unrelated A and B compounds that act synergistically in vivo against gram-positive pathogens, such as staphylococci, streptococci, and enterococci (8, 11). Resistance against B compounds is very widespread among enterococci and is mediated via the ermBgene cluster (e.g., on Tn917) that confers macrolide-lincosamide-streptogramin B resistance (7). The...

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