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Article

Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006

Bewley Maria C, Graziano Vito, Jiang Jiangsheng, Matz Eileen, Studier F William, Pegg Anthony E, Coleman Catherine S, Flanagan John M

Abstract excerpt

Spermidine/spermine N1-acetyltransferase (SSAT) is a key enzyme in the control of polyamine levels in human cells, as acetylation of spermidine and spermine triggers export or degradation. Increased intracellular polyamine levels accompany several types of cancers as well as other human diseases, and compounds that affect the expression, activity, or stability of SSAT are being explored as potential therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16455797
DOI: 10.1073/pnas.0511008103
PMCID: PMC1360125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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