Article
Beyond PrP9res) type 1/type 2 dichotomy in Creutzfeldt-Jakob disease.
PLoS pathogens - 14 Mar 2008
Uro-Coste Emmanuelle, Cassard Hervé, Simon Stéphanie, Lugan Séverine, Bilheude Jean-Marc, Perret-Liaudet Armand, Ironside James W, Haik Stéphane, Basset-Leobon Christelle, Lacroux Caroline, Peoch' Katell, Streichenberger Nathalie, Langeveld Jan, Head Mark W, Grassi Jacques, Hauw Jean-Jacques, Schelcher Francois, Delisle Marie Bernadette, Andréoletti Olivier
Abstract excerpt
Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently subclassified according to the methionine/valine polymorphism at codon 129 of the PRNP gene and the proteinase K (PK) digested abnormal prion protein (PrP(res)) identified on Western blotting (type 1 or type 2). These biochemically distinct PrP(res) types have been considered to represent potential distinct prion strains. However, since cases of CJD...
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