Article
Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2004
Casalone Cristina, Zanusso Gianluigi, Acutis Pierluigi, Ferrari Sergio, Capucci Lorenzo, Tagliavini Fabrizio, Monaco Salvatore, Caramelli Maria
Abstract excerpt
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are mammalian neurodegenerative disorders characterized by a posttranslational conversion and brain accumulation of an insoluble, protease-resistant isoform (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)). Human and animal TSE agents exist as different phenotypes that can be biochemically differentiated on the basis of the...
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