Article
Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment.
The American journal of pathology - 1 Feb 2002
Ohno-Matsui Kyoko, Hirose Akira, Yamamoto Satoru, Saikia Jina, Okamoto Naoyuki, Gehlbach Peter, Duh Elia J, Hackett Sean, Chang Michelle, Bok Dean, Zack Donald J, Campochiaro Peter A
Abstract excerpt
Transgenic mice with vascular endothelial growth factor (VEGF) driven by the rhodopsin promoter (rho/VEGF mice) develop neovascularization that originates from the deep capillary bed of the retina and grows into the subretinal space. In rho/VEGF mice, VEGF expression in photoreceptors begins between postnatal days 5 and 7, the period when the deep capillary bed is developing. An important question is whether or...
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