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Article

Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease.

The Journal of cell biology - 29 Oct 2012

Selvaraj Bhuvaneish Thangaraj, Frank Nicolas, Bender Florian L P, Asan Esther, Sendtner Michael

Abstract excerpt

Axonal maintenance, plasticity, and regeneration are influenced by signals from neighboring cells, in particular Schwann cells of the peripheral nervous system. Schwann cells produce neurotrophic factors, but the mechanisms by which ciliary neurotrophic factor (CNTF) and other neurotrophic molecules modify the axonal cytoskeleton are not well understood. In this paper, we show that activated signal transducer and...

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Source

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Identifiers

PMID: 23109669
DOI: 10.1083/jcb.201203109
PMCID: PMC3483126

Genes

STAT3
CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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