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Article

A Hypothetical Mechanism for Fetal Alcohol Syndrome Involving Ethanol Inhibition of Retinoic Acid Synthesis at the Alcohol Dehydrogenase Step

1 Jun 1991

Abstract excerpt

Ethanol acts as a teratogen causing brain, craniofacial, and limb abnormalities in those suffering from fetal alcohol syndrome. Normal embryonic development of the vertebrate nervous system and limbs has recently been shown to be governed by retinoic acid, the active form of vitamin A. Retinol dehydrogenase is an enzyme needed to convert vitamin A (retinol) to retinoic acid, a molecule that specifies embryonic...

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PMID: 1877746
DOI: 10.1111/j.1530-0277.1991.tb00562.x

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A Hypothetical Mechanism for Fetal Alcohol Syndrome Involving Ethanol Inhibition of Retinoic Acid Synthesis at the Alcohol Dehydrogenase StepPMID 1877746Read ↗

The Interaction of Ethanol and Vitamin A as a Potential Mechanism for the Pathogenesis of Fetal Alcohol SyndromeSemantic proximity Read ↗

Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation.Semantic proximity Read ↗

Hypothesis: Prenatal Ethanol‐Induced Birth Defects and Retinoic AcidSemantic proximity Read ↗

Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase.Semantic proximity Read ↗

Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorderSemantic proximity Read ↗

Perturbation of retinoic acid (RA)‐mediated limb development suggests a role for diminished RA signaling in the teratogenesis of ethanolSemantic proximity Read ↗

Analysis of alcohol-metabolizing enzymes genetic variants and RAR/RXR expression in patients diagnosed with fetal alcohol syndrome: a case-control study.Semantic proximity Read ↗

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METABOLIC AND MITOTIC CHANGES ASSOCIATED WITH THE FETAL ALCOHOL SYNDROMESemantic proximity Read ↗

Zebrafish fetal alcohol syndrome model: effects of ethanol are rescued by retinoic acid supplementSemantic proximity Read ↗

Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid.Semantic proximity Read ↗

Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice.Semantic proximity Read ↗

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