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Article

Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium.

American journal of physiology. Renal physiology - 1 Mar 2002

Yoder Bradley K, Tousson Albert, Millican Leigh, Wu John H, Bugg Charles E, Schafer James A, Balkovetz Daniel F

Abstract excerpt

Cilia are organelles that play diverse roles, from fluid movement to sensory reception. Polaris, a protein associated with cystic kidney disease in Tg737(o)(rpk) mice, functions in a ciliogenic pathway. Here, we explore the role of polaris in primary cilia on Madin-Darby canine kidney cells. The results indicate that polaris localization and solubility change dramatically during cilia formation. These changes...

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Identifiers

PMID: 11832437
DOI: 10.1152/ajprenal.00273.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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