Article
Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium.
PloS one - 1 Jan 2011
Pluznick Jennifer L, Rodriguez-Gil Diego J, Hull Michael, Mistry Kavita, Gattone Vincent, Johnson Colin A, Weatherbee Scott, Greer Charles A, Caplan Michael J
Abstract excerpt
It was reported that some proteins known to cause renal cystic disease (NPHP6; BBS1, and BBS4) also localize to the olfactory epithelium (OE), and that mutations in these proteins can cause anosmia in addition to renal cystic disease. We demonstrate here that a number of other proteins associated with renal cystic diseases - polycystin 1 and 2 (PC1, PC2), and Meckel-Gruber syndrome 1 and 3 (MKS1, MKS3) - localize...
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