Article
Novel fibrillar structure in the inversin compartment of primary cilia revealed by 3D single-molecule superresolution microscopy.
Molecular biology of the cell - 19 Mar 2020
Bennett Henrietta W, Gustavsson Anna-Karin, Bayas Camille A, Petrov Petar N, Mooney Nancie, Moerner W E, Jackson Peter K
Abstract excerpt
Primary cilia in many cell types contain a periaxonemal subcompartment called the inversin compartment. Four proteins have been found to assemble within the inversin compartment: INVS, ANKS6, NEK8, and NPHP3. The function of the inversin compartment is unknown, but it appears to be critical for normal development, including left-right asymmetry and renal tissue homeostasis. Here we combine superresolution imaging...
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