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Article

Vps33b is crucial for structural and functional hepatocyte polarity.

Journal of hepatology - 1 May 2017

Hanley Joanna, Dhar Dipok Kumar, Mazzacuva Francesca, Fiadeiro Rebeca, Burden Jemima J, Lyne Anne-Marie, Smith Holly, Straatman-Iwanowska Anna, Banushi Blerida, Virasami Alex, Mills Kevin, Lemaigre Frédéric P, Knisely A S, Howe Steven, Sebire Neil, Waddington Simon N, Paulusma Coen C, Clayton Peter, Gissen Paul

Abstract excerpt

BACKGROUND & AIMS: In the normal liver, hepatocytes form a uniquely polarised cell layer that enables movement of solutes from sinusoidal blood to canalicular bile. Whilst several cholestatic liver diseases with defects of hepatocyte polarity have been identified, the molecular mechanisms of pathogenesis are not well defined. One example is arthrogryposis, renal dysfunction and cholestasis syndrome, which in most...

Topics

Animals
Arthrogryposis
Bile Acids and Salts
Cell Polarity
Cholestasis
Cholesterol
Genetic Therapy
Hepatocytes
Liver
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mutation

Renal Insufficiency

Tight Junctions

Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28082148
DOI: 10.1016/j.jhep.2017.01.001
PMCID: PMC5387182

Genes

ARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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