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Article

Genetic Analysis of the Mammalian K+ Channel β Subunit Kvβ2 (Kcnab2)

1 Apr 2002

Abstract excerpt

Kvbeta2 binds to K(+) channel alpha subunits from at least two different families (Kv1 and Kv4) and is a member of the aldo-ketoreductase (AKR) superfamily. Proposed functions for this protein in vivo include a chaperone-like role in Kv1 alpha subunit biogenesis and catalytic activity as an AKR oxidoreductase. To investigate the in vivo function of Kvbeta2, Kvbeta2-null and point mutant (Y90F) mice were generated...

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PMID: 11825900
DOI: 10.1074/jbc.m111465200

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