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Article

Na,K-ATPase subunit beta1 knock-in prevents lethality of beta2 deficiency in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 1998

Weber P, Bartsch U, Schachner M, Montag D

Abstract excerpt

The beta2 subunit of the Na,K-ATPase displays functional properties of both an integral constituent of an ion pump and an adhesion and neurite outgrowth-promoting molecule in vitro. To investigate whether the beta1 subunit of the Na,K-ATPase can functionally substitute for the beta2 isoform in vivo, we have generated beta2/beta1 knock-in mice by homologous recombination in embryonic stem cells. In beta2/beta1...

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PMID: 9801359
PMCID: PMC6792892

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