Article
Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2011
Jorge Benjamin S, Campbell Courtney M, Miller Alison R, Rutter Elizabeth D, Gurnett Christina A, Vanoye Carlos G, George Alfred L, Kearney Jennifer A
Abstract excerpt
Mutations in voltage-gated ion channels are responsible for several types of epilepsy. Genetic epilepsies often exhibit variable severity in individuals with the same mutation, which may be due to variation in genetic modifiers. The Scn2a(Q54) transgenic mouse model has a sodium channel mutation and exhibits epilepsy with strain-dependent severity. We previously mapped modifier loci that influence Scn2a(Q54)...
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