Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2002

Ihn Hironobu, Yamane Kenichi, Asano Yoshihide, Kubo Masahide, Tamaki Kunihiko

Abstract excerpt

Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a potent inhibitor of activated matrix metalloproteinases such as gelatinase and collagenase, and thus helps to control extracellular matrix metabolism and deposition by connective tissue cells. We examined the responsiveness of the expression of TIMP-2 to various cytokines in dermal fibroblasts and studied the regulatory and signaling mechanisms of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermis
Share to Imidazoles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-4

Share to MAP Kinase Signaling System

Share to Mitogen-Activated Protein Kinases

Share to p38 Mitogen-Activated Protein Kinases

Share to Pyridines

Share to Tissue Inhibitor of Metalloproteinase-2

Source

Identifiers

PMID: 11823524
DOI: 10.4049/jimmunol.168.4.1895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway.PMID 11823524Read ↗

Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironmentSemantic proximity Read ↗

Tissue Inhibitor of Metalloproteinases-4. The road less traveledSemantic proximity Read ↗

Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancerSemantic proximity Read ↗

Elucidating the Cellular Mechanism for E2-induced Dermal FibrosisSemantic proximity Read ↗

Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.Semantic proximity Read ↗

Tissue inhibitors of metalloproteinases (TEMP) in invasion and proliferationSemantic proximity Read ↗

TIMP-2 Is Required for Efficient Activation of proMMP-2 in VivoSemantic proximity Read ↗

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.Semantic proximity Read ↗

TGF-β-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts.Semantic proximity Read ↗

Timp‐2 binding with cellular MT1‐MMP stimulates invasion‐promoting MEK/ERK signaling in cancer cellsSemantic proximity Read ↗

Activation of Extracellular Signal-regulated Kinase 1/2 Inhibits Type I Collagen Expression by Human Skin FibroblastsSemantic proximity Read ↗

TIMP-1 attenuates the development of cutaneous inflammation-induced evoked and ongoing pain through receptor-mediated cell signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.