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Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation

1 Apr 1996

Abstract excerpt

Previous studies have demonstrated the presence of amyloid beta (Abeta) in neurons (NT2N) derived from a human embryonal carcinoma cell line (NT2) by steady state metabolic radiolabeling and immunoprecipitation. We show here that Abeta is present intracellularly since trypsin digestion of intact NT2N cells at 4 degrees C did not eliminate the Abeta recovered in cell lysates. To determine whether both Abeta40 and...

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PMID: 8621541
DOI: 10.1074/jbc.271.15.8966

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