Article
Structure-function relationships of the luteinizing hormone receptor.
Annals of the New York Academy of Sciences - 1 Dec 2005
Puett David, Li Yongsheng, Angelova Krassimira, Demars Geneva, Meehan Thomas P, Fanelli Francesca, Narayan Prema
Abstract excerpt
Of the 800-900 genes in the human genome that appear to encode G-protein-coupled receptors (GPCRs), two are known to encode receptors that bind the three heterodimeric human gonadotropins, luteinizing hormone (LH), chorionic gonadotropin (CG), and follicle-stimulating hormone (FSH). LH and CG bind to a common receptor, LHR, and FSH binds to a paralogous receptor. These GPCRs contain a relatively large ectodomain...
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