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Article

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

Oncogene - 25 Oct 2007

Shtiegman K, Kochupurakkal B S, Zwang Y, Pines G, Starr A, Vexler A, Citri A, Katz M, Lavi S, Ben-Basat Y, Benjamin S, Corso S, Gan J, Yosef R B, Giordano S, Yarden Y

Abstract excerpt

Several distinct mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are associated with non-small cell lung cancer, but mechanisms underlying their oncogenic potential are incompletely understood. Although normally ligand-induced kinase activation targets EGFR to Cbl-mediated receptor ubiquitinylation and subsequent degradation in lysosomes, we report that certain EGFR mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17486068
DOI: 10.1038/sj.onc.1210503

Genes

EGFR

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.PMID 17486068Read ↗

Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutantsSemantic proximity Read ↗

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Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized.Semantic proximity Read ↗

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Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptorsSemantic proximity Read ↗

Gefitinib-sensitive EGFR lacking residues 746-750 exhibits hypophosphorylation at tyrosine residue 1045, hypoubiquitination, and impaired endocytosis.Semantic proximity Read ↗

A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.Semantic proximity Read ↗

ARF promotes the degradation of the Epidermal Growth Factor Receptor by the lysosome.Semantic proximity Read ↗

c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes.Semantic proximity Read ↗

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.Semantic proximity Read ↗

[Ubiquitination-mediated degradation of epidermal growth factor receptor].Semantic proximity Read ↗

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.Semantic proximity Read ↗

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