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Article

Breakpoints in the ataxia telangiectasia gene arise at the RGYW somatic hypermutation motif.

Oncogene - 17 Jan 2002

Bradshaw Paul S, Condie Alison, Matutes Estella, Catovsky Daniel, Yuille Martin R

Abstract excerpt

The mature sporadic T-cell malignancy, T-cell prolymphocytic leukemia (T-PLL) is remarkable for frequently harbouring somatic mutations of the Ataxia Telangiectasia (A-T) gene, ATM. Because some data suggest ATM is frequently rearranged in T-PLL, it was decided to investigate such rearrangements in detail by cloning breakpoints. Among 17 T-PLL tumour samples, three rearrangements were detected by Southern...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11821961
DOI: 10.1038/sj.onc.1205105

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Breakpoints in the ataxia telangiectasia gene arise at the RGYW somatic hypermutation motif.PMID 11821961Read ↗

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