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Article

Quantitative assessment of mutant allele burden in solid tumors by semiconductor-based next-generation sequencing.

American journal of clinical pathology - 1 Apr 2014

Portier Bryce P, Kanagal-Shamanna Rashmi, Luthra Rajyalakshmi, Singh Rajesh, Routbort Mark J, Handal Brian, Reddy Neelima, Barkoh Bedia A, Zuo Zhuang, Medeiros L Jeffrey, Aldape Kenneth, Patel Keyur P

Abstract excerpt

OBJECTIVES: Identification of tumor-specific somatic mutations has had a significant impact on both disease diagnosis and therapy selection. The ability of next-generation sequencing (NGS) to provide a quantitative assessment of mutant allele burden, in numerous target genes in a single assay, provides a significant advantage over conventional qualitative genotyping platforms. METHODS: We assessed the...

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PMID: 24619758
DOI: 10.1309/AJCP1JUGQMW7ZNTL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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