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Article

Probing the<i>cis</i>-arrangement of prototype tight junction proteins claudin-1 and claudin-3

9 Apr 2015

Abstract excerpt

Claudins form a large family of TJ (tight junction) proteins featuring four transmembrane segments (TM1-TM4), two extracellular loops, one intracellular loop and intracellular N- and C-termini. They form continuous and branched TJ strands by homo- or heterophilic interaction within the same membrane (cis-interaction) and with claudins of the opposing lateral cell membrane (trans-interaction). In order to clarify...

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PMID: 25849148
DOI: 10.1042/bj20150148

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