Article
One Hundred Years of Linkage Disequilibrium.
Genetics - 1 Jul 2018
Sved John A, Hill William G
Abstract excerpt
One hundred years ago, the first population genetic calculations were made for two loci. They indicated that populations should settle down to a state where the frequency of an allele at one locus is independent of the frequency of an allele at a second locus, even if these loci are linked. Fifty years later it was realized what is obvious in retrospect, that these calculations ignored the effect of chance...
Topics
- Animals
- Chromosome Mapping
- Evolution, Molecular
- Gene Frequency
- Genetic Predisposition to Disease
- Genetics, Population
- Humans
- Linkage Disequilibrium
- Polymorphism, Single Nucleotide
- Population Density
- Quantitative Trait Loci