Article
One Hundred Years of Linkage Disequilibrium.
Genetics - 1 Jul 2018
Sved John A, Hill William G
Abstract excerpt
One hundred years ago, the first population genetic calculations were made for two loci. They indicated that populations should settle down to a state where the frequency of an allele at one locus is independent of the frequency of an allele at a second locus, even if these loci are linked. Fifty years later it was realized what is obvious in retrospect, that these calculations ignored the effect of chance...
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