Article
Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Feb 2002
Yoshida Keizo, Ito Kenichi, Sato Kazuhiro, Takahashi Hitoshi, Kamata Mitsuhiro, Higuchi Hisashi, Shimizu Tetsuo, Itoh Kunihiko, Inoue Kazuyuki, Tezuka Takehiko, Suzuki Toshio, Ohkubo Tadashi, Sugawara Kazunobu, Otani Koichi
Abstract excerpt
The presence of the long (l) variant of the serotonin (5-hydroxytryptamine: 5-HT) transporter gene-linked polymorphic region (5-HTTLPR) is reported to be associated with a more favorable and faster antidepressant effect of selective serotonin reuptake inhibitors in Caucasians. The frequency of the l allele is lower in Japanese than in Caucasians; therefore, the antidepressant effect of fluvoxamine can be not as...
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