Article

An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates

2020-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Excitatory amino acid transporters (EAATs) are prototypic dual function proteins that function as coupled glutamate/Na + /H + /K + transporters and as anion-selective channels. Both transport functions are intimately intertwined at the structural level: secondary active glutamate transport is based on elevator-like movements of the mobile transport domain across the membrane, and the lateral...

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Literature Corpus work: 4bf0b6cf-e28a-5e66-bb18-e4ceb1e5cc4e
DOI: 10.1101/2020.04.08.031997

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