Article
Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment.
Environmental and molecular mutagenesis - 1 Jan 2002
Ono-Ogata Tomoko, Ogino Tomoe, Nishikawa Michiko, Ohta Toshihiro, Yamagata Hideo
Abstract excerpt
We examined the mutagenic activities of six antiprotozoal drugs (three diaminopyrimidine compounds [pyrimethamine, diaveridine, and trimethoprim] and three 8-aminoquinoline derivatives [primaquine, pentaquine, and pamaquine]) in Escherichia coli WP2uvrA/pKM101 and Salmonella typhimurium TA100 and TA98 with and without nitrite treatment. The diaminopyrimidine compounds showed no mutagenic activity under any...
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