Article
Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.
European journal of immunology - 1 Feb 2002
Marinari Barbara, Costanzo Antonio, Viola Antonella, Michel Frederique, Mangino Giorgio, Acuto Oreste, Levrero Massimo, Piccolella Enza, Tuosto Loretta
Abstract excerpt
CD28-delivered costimulatory signals are required to induce NF-kappaB activation in response to TCR stimulation. We have recently demonstrated that the mitogen-activated kinase kinase 1 (MEKK1), a kinase known to regulate the c-jun N-terminal kinase (JNK) pathway, is also involved in the CD28- and TCR-induced inhibitor of kappaB factor (IkappaB) kinases (IKK) and NF-kappaB activation. Searching for molecules that...
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