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Article

Rac is involved in early TCR signaling.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2000

Arrieumerlou C, Randriamampita C, Bismuth G, Trautmann A

Abstract excerpt

The GTPase Rac controls signaling pathways often related to actin polymerization in various cell types. In T lymphocytes, Rac is activated by Vav, a major component of the multiprotein transduction complex associated to the TCR. Although profound signaling defects have been observed in Vav-deficient mice, a role of Rac in the corresponding early TCR signaling has not been tested directly. This question was...

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PMID: 10975833
DOI: 10.4049/jimmunol.165.6.3182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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