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Article

Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA.

The Journal of cell biology - 19 Apr 1999

Meeusen S, Tieu Q, Wong E, Weiss E, Schieltz D, Yates J R, Nunnari J

Abstract excerpt

Maintenance of mitochondrial DNA (mtDNA) during cell division is required for progeny to be respiratory competent. Maintenance involves the replication, repair, assembly, segregation, and partitioning of the mitochondrial nucleoid. MGM101 has been identified as a gene essential for mtDNA maintenance in S. cerevisiae, but its role is unknown. Using liquid chromatography coupled with tandem mass spectrometry, we...

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Identifiers

PMID: 10209025
DOI: 10.1083/jcb.145.2.291
PMCID: PMC2133103

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