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Article

Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.

The Journal of biological chemistry - 28 Feb 2003

Miggin Sinead M, Lawler Orlaith A, Kinsella B Therese

Abstract excerpt

We have previously established that isoprenylation of the prostacyclin receptor (IP) is required for its efficient G protein coupling and effector signaling (Hayes, J. S., Lawler, O. A., Walsh, M. T., and Kinsella, B. T. (1999) J. Biol. Chem. 274, 23707-23718). In the present study, we sought to investigate whether the IP may actually be subject to palmitoylation in addition to isoprenylation and to establish the...

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PMID: 12488443
DOI: 10.1074/jbc.M210637200

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