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Article

An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization.

Molecular biology of the cell - 1 Jul 2005

Moriarty Tara J, Ward Ryan J, Taboski Michael A S, Autexier Chantal

Abstract excerpt

Telomerase-mediated telomeric DNA synthesis is important for eukaryotic cell immortality. Telomerase adds tracts of short telomeric repeats to DNA substrates using a unique repeat addition form of processivity. It has been proposed that repeat addition processivity is partly regulated by a telome...

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Identifiers

PMID: 15857955
DOI: 10.1091/mbc.e05-02-0148
PMCID: PMC1165400

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15857955-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization.PMID 15857955Read ↗

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The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity.Semantic proximity Read ↗

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