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Article

Effect of genetic circular permutation near the active site on the activity and stability of an enzyme inhibitor.

Biomolecular engineering - 1 Jan 2004

Piervincenzi Ronald T, Chilkoti Ashutosh

Abstract excerpt

We report here the effect of circular permutation on the structure and function of a model protein tendamistat, a 74 amino acid competitive inhibitor of porcine pancreatic alpha-amylase. The activity and stability of wild type and two permuted tendamistat variants were characterized by measuremen...

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Identifiers

PMID: 14715318
DOI: 10.1016/s1389-0344(03)00080-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14715318-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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