Article
FcgammaRIIa polymorphism and clinical response to rituximab in non-Hodgkin lymphoma patients.
Cancer genetics and cytogenetics - 1 May 2008
Paiva Márcia, Marques Herlander, Martins Angelo, Ferreira Paula, Catarino Raquel, Medeiros Rui
Abstract excerpt
Rituximab is a chimeric monoclonal antibody that specifically targets the CD20 surface marker expressed in neoplastic B-lymphoid cells. Combined with chemotherapy or alone, in maintenance/consolidation, it is used for the treatment of non-Hodgkin lymphoma (NHL). The role of a polymorphism in a specific Fc gamma receptor gene, FcgammaRIIa, in the clinical outcome of patients with NHL was investigated in this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
