Article
Implications on zinc binding to S100A2.
Biochimica et biophysica acta - 1 Mar 2007
Koch Michael, Bhattacharya Shibani, Kehl Torsten, Gimona Mario, Vasák Milan, Chazin Walter, Heizmann Claus W, Kroneck Peter M H, Fritz Günter
Abstract excerpt
Human S100A2 is an EF-hand calcium-binding S100 protein that is localized mainly in the nucleus and functions as tumor suppressor. In addition to Ca2+ S100A2 binds Zn2+ with a high affinity. Studies have been carried out to investigate whether Zn2+ acts as a regulatory ion for S100A2, as in the case of Ca2+. Using the method of competition with the Zn2+ chelator 4-(2-pyridylazo)-resorcinol, an apparent Kd of 25...
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