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Article

Two-metal-Ion catalysis in adenylyl cyclase.

Science (New York, N.Y.) - 30 Jul 1999

Tesmer J J, Sunahara R K, Johnson R A, Gosselin G, Gilman A G, Sprang S R

Abstract excerpt

Adenylyl cyclase (AC) converts adenosine triphosphate (ATP) to cyclic adenosine monophosphate, a ubiquitous second messenger that regulates many cellular functions. Recent structural studies have revealed much about the structure and function of mammalian AC but have not fully defined its active site or catalytic mechanism. Four crystal structures were determined of the catalytic domains of AC in complex with two...

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PMID: 10427002
DOI: 10.1126/science.285.5428.756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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