Article
Possible association between higher beta-catenin mRNA expression and mutated beta-catenin in sporadic desmoid tumors: real-time semiquantitative assay by TaqMan polymerase chain reaction.
Laboratory investigation; a journal of technical methods and pathology - 1 Jan 2002
Saito Tsuyoshi, Oda Yoshinao, Kawaguchi Ken-ichi, Tanaka Kazuhiro, Matsuda Shuichi, Tamiya Sadafumi, Iwamoto Yukihide, Tsuneyoshi Masazumi
Abstract excerpt
We screened for genetic alterations of adenomatous polyposis coli (APC) and beta-catenin genes in 17 frozen specimens from 12 cases of sporadic desmoid tumors and then subdivided these cases into two groups according to the results of mutational analysis. We further examined mRNA expression of beta-catenin and cyclin D1 by TaqMan PCR and compared the mRNA expression within both groups. Single-strand conformation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.