Article
Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis.
Cancer research - 1 Nov 1993
Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Tanaka K, Takahashi H, Muraoka M, Mori T, Konishi F, Iwama T
Abstract excerpt
Desmoid tumors, which are locally invasive with recurrence but without metastasis, are frequently observed in patients with familial adenomatous polyposis after abdominal surgery or during pregnancy. This study analyzed mutation of the adenomatous polyposis coli gene in 8 desmoid tumors from 7 fa...
Topics
- Adenomatous Polyposis Coli
- Adult
- Base Sequence
- Chromosome Aberrations
- Codon
- Colorectal Neoplasms
- Exons
- Female
- Desmoid Tumors
- Genes, APC
- Genes, ras
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Point Mutation
- Polymerase Chain Reaction