Article
Intrathoracic sporadic desmoid tumor with the beta-catenin gene mutation in exon 3 and activated cyclin D1.
Respiration; international review of thoracic diseases - 1 Jan 2006
Tajima Shunji, Hironaka Mitsugu, Oshikawa Katsuhisa, Bando Masashi, Ohno Shoji, Saito Ken, Sohara Yasunori, Sugiyama Yukihiko
Abstract excerpt
We report a case of intrathoracic desmoid tumor without familial adenomatous polyposis and demonstrate beta-catenin mutation of exon 3. A 15-year-old male presented with a desmoid tumor after having sustained an assault. In an examination for a mutation of the beta-catenin gene, an activating mutation from ACC (Thr) to GCC (Ala) at codon 41 was found. Immunohistochemical staining showed that accumulated...
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