Article
Human microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations.
Oncotarget - 27 Jun 2017
Cavallini Aldo, Rotelli Maria Teresa, Lippolis Catia, Piscitelli Domenico, Digennaro Rosa, Covelli Claudia, Carella Nicola, Accetturo Matteo, Altomare Donato Francesco
Abstract excerpt
Desmoid tumors (DT) are rare, benign, fibroblastic neoplasm with challenging histological diagnosis. DTs can occur sporadically or associated with the familial adenomatous polyposis coli (FAP). Most sporadic DTs are associated with β-catenin gene (CTNNB1) mutations, while mutated APC gene causes FAP disease. microRNAs (miRNAs) are involved in many human carcinogenesis.The miRNA profile was analyzed by microarray...
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