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Article

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis

24 Jan 2005

Abstract excerpt

The causative pathomechanism of sporadic amyotrophic lateral sclerosis (ALS) is not clearly understood. Using microarray technology combined with laser-captured microdissection, gene expression profiles of degenerating spinal motor neurons isolated from autopsied patients with sporadic ALS were examined. Gene expression was quantitatively assessed by real-time reverse transcription polymerase chain reaction and...

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PMID: 15668976
DOI: 10.1002/ana.20379

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