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Article

Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome.

The EMBO journal - 1 Sept 1992

Bartenschlager R, Schaller H

Abstract excerpt

Hepadnaviruses, as well as other pararetroviruses, express their pol (P) gene product unfused to the preceding core gene implying that these retroelements have developed a mechanism for initiating assembly and replication that is principally different from the one used by retroviruses and retrotransposons. We have analysed this mechanism for the human hepatitis B virus by using a newly developed, highly sensitive...

Topics

Capsid
Cell Line
DNA, Recombinant
DNA-Directed DNA Polymerase
Gene Products, pol
Hepatitis B virus
Humans
Isotope Labeling
Mutation
Phosphorus Radioisotopes
Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

RNA-Directed DNA Polymerase

Viral Core Proteins

Viral Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1380455
DOI: 10.1002/j.1460-2075.1992.tb05420.x
PMCID: PMC556876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1380455-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome.PMID 1380455Read ↗

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Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription.Semantic proximity Read ↗

Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex.Semantic proximity Read ↗

A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesisSemantic proximity Read ↗

A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA.Semantic proximity Read ↗

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Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses.Semantic proximity Read ↗

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Structure and function of the encapsidation signal of hepadnaviridae.Semantic proximity Read ↗

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cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA.Semantic proximity Read ↗

Evidence that the 5'-end cap structure is essential for encapsidation of hepatitis B virus pregenomic RNA.Semantic proximity Read ↗

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