Article
Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 2002
Bondolfi Luca, Calhoun Michael, Ermini Florian, Kuhn H Georg, Wiederhold Karl-Heinz, Walker Lary, Staufenbiel Matthias, Jucker Mathias
Abstract excerpt
APP23 transgenic mice express mutant human amyloid precursor protein and develop amyloid plaques predominantly in neocortex and hippocampus progressively with age, similar to Alzheimer's disease. We have previously reported neuron loss in the hippocampal CA1 region of 14- to 18-month-old APP23 mice. In contrast, no neuron loss was found in neocortex. In the present study we have reinvestigated neocortical neuron...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.