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Article

UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan.

BMC neurology - 28 Jul 2012

Miyake Yoshihiro, Tanaka Keiko, Fukushima Wakaba, Kiyohara Chikako, Sasaki Satoshi, Tsuboi Yoshio, Yamada Tatsuo, Oeda Tomoko, Shimada Hiroyuki, Kawamura Nobutoshi, Sakae Nobutaka, Fukuyama Hidenao, Hirota Yoshio, Nagai Masaki

Abstract excerpt

BACKGROUND: A recent meta-analysis on the UCHL1 S18Y variant and Parkinson's disease (PD) showed a significant inverse association between the Y allele and PD; the individual studies included in that meta-analysis, however, have produced conflicting results. We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan. METHODS: Included were 229 cases within 6...

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Source

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Identifiers

PMID: 22839974
DOI: 10.1186/1471-2377-12-62
PMCID: PMC3488468

Genes

UCHL1
SNCA

Variants

Provenance

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Related research

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Research trail→

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UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan.PMID 22839974Read ↗

Lack of association between UCHL1 S18Y gene polymorphism and Parkinson's disease in the Asian population: a meta-analysis.Semantic proximity Read ↗

The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.Semantic proximity Read ↗

UCHL-1 is not a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

Case-control study of UCHL1 S18Y variant in Parkinson's disease.Semantic proximity Read ↗

UCHL1 is a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.Semantic proximity Read ↗

Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease.Semantic proximity Read ↗

S18Y polymorphism in the UCH-L1 gene and Parkinson's disease: evidence for an age-dependent relationship.Semantic proximity Read ↗

Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis.Semantic proximity Read ↗

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population.Semantic proximity Read ↗

Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population.Semantic proximity Read ↗

S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden.Semantic proximity Read ↗

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