Article
Confirmation of correlations and common quantitative trait loci between neurotensin receptor density and hypnotic sensitivity to ethanol.
Alcoholism, clinical and experimental research - 1 Dec 2001
Erwin V G, Gehle V M, Davidson K, Radcliffe R A
Abstract excerpt
BACKGROUND: In previous studies, genetic correlations were observed between hypnotic sensitivity to ethanol and high-affinity neurotensin receptor (NTS1) binding. Provisional quantitative trait loci (QTLs) were identified for these traits, and some of these QTLs were found on common chromosomal regions. In continued efforts to examine the relationship between NTS1 binding capacity and hypnotic sensitivity to...
Topics
- Animals
- Chromosome Mapping
- Corpus Striatum
- Ethanol
- Female
- Hypnotics and Sedatives
- Male
- Mice
- Mice, Inbred Strains
- Phenotype
- Postural Balance
- Quantitative Trait, Heritable
- Rats
- Rats, Inbred Strains
- Receptors, Neurotensin
- Reflex
