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The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

24 Oct 2006

Abstract excerpt

Growth factor signaling is mediated through Class IA phosphatidylinositol 3-kinases (PI3Ks). Among this class of enzymes, only p110alpha, encoded by the PIK3CA gene, has been found to be mutant in human cancers. To determine the specific functions of p110alpha, we generated mice carrying a conditionally targeted allele of the PIK3CA gene. Here, we report that PIK3CA-knockout mouse embryonic fibroblasts are...

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PMID: 17060635
DOI: 10.1073/pnas.0607899103

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